But such early enthusiasm for the compound, made using a toxic shrub, is not only strange, but disturbing, three infectious disease specialists told CNN Monday.
It’s only been tested in laboratory dishes and is very unlikely to end up as a treatment for the infection, they said.
“This is really just nonsense and a distraction,” Dr. Jonathan Reiner, CNN medical analyst and a professor of medicine at George Washington University, told CNN’s Anderson Cooper.
“But I can tell you there are millions of compounds that, when tested in vitro, in a test tube, appear to have some antiviral activity but that are worthless in vivo, in humans.”
The research itself is solid, performed by a team led by Scott Weaver of the World Reference Center for Emerging Viruses and Arboviruses at the University of Texas Medical Branch. “Oleandrin has been recognized as the active principle ingredient in oleander extracts used in Phase I and Phase II clinical trials of patients with cancer,” they wrote.
“These trials defined the pharmacokinetics of oleandrin and demonstrated that extracts containing this molecule could be given safely as an oral drug to patients without significant adverse events. Less appreciated is the strong antiviral activity of this class of compounds.” Their tests of the compound in monkey cells grown in lab dishes suggested it could inactivate coronavirus.
But the researchers added that animal tests are needed before any further discussion of the use of the drug against coronavirus.
Dr. Peter Hotez, dean of the school of tropical medicine at Baylor College of Medicine, agreed. “It should be added to the growing list of compounds that are tested in laboratory animals. That’s it,” Hotez told Cooper. “The likelihood that this would actually emerge as a proven therapy is still remote,” he added. “Even after animal testing it could still fail in clinical trials.”
Last week, Lindell was added to the board of Phoenix Biotechnology, which makes oleandrin, and received a financial stake in the company.
Trump said he had “heard about” oleandrin. “Is it something people are talking about very strongly?” he asked a reporter on the White House lawn.
“We’ll look at it, we’ll look at it, we’re looking at a lot of different things,” he said.
Hotez said he could not understand why the administration would focus on this particular product. “Why pivot towards this?” he asked. “It’s somewhat odd or bizarre the way the President or the White House tends to go for these really strange types of miracle cures.”
Dr. William Schaffner, an infectious disease specialist at Vanderbilt University, has some simple advice for the public. “Don’t take it. Stay away. This is quackery,” he told CNN’s Jake Tapper. “Do not take medications of any kind to either prevent this infection or to treat it that hasn’t been vetted very, very carefully by the scientific community.”