On Thursday, the US Food and Drug Administration’s vaccine advisers recommended the agency grant emergency use authorization to the Covid-19 vaccine developed by Pfizer and BioNTech.
While the EUA falls shorts of a full approval, the FDA’s authorization would be a first in the US and a remarkable achievement, coming about a year after the coronavirus emerged.
The FDA has yet to make a final decision about an EUA, but a source close to the White House coronavirus task force said it could come as early as late Friday.
In the meantime, here’s what we know about Pfizer’s Covid-19 vaccine.
Who will get it first?
Once the FDA decides to grant an EUA, the US Center for Disease Control and Prevention’s Advisory Committee for Immunization Practices (ACIP) will meet and vote on whether to recommend the vaccine. Once the CDC accepts the recommendation, vaccinations can begin.
That ACIP vote could come Saturday or Sunday.
Keeping doctors and nurses healthy will be important for the continuing fight against the virus, which will stretch on for months, even after a vaccine is authorized. But Romero said that first group also includes other people working in health care institutions, like those who deliver food and perform housekeeping.
“Anybody that works within a health care institution that could have contact with an individual who has Covid should receive vaccination,” Romero previously told CNN.
Residents of long-term care facilities like nursing homes also need the protection. So far, they account for about 40% of coronavirus deaths in the US.
Gen. Gustave Perna, chief operating officer of the federal government vaccine initiative Operation Warp Speed, previously said he believed vaccine administration will be able to begin vaccinations within 96 hours of authorization.
CVS, which is preparing to begin vaccinations in long-term care facilities, said that December 21 would be the earliest vaccine administration can start in the facilities.
“We’ll be in facilities that day in states that choose to begin as soon as possible,” spokesman Ethan Slavin said.
The FDA is set to make a decision on a separate vaccine candidate by Moderna in the coming days. If it’s also authorized, it’s possible that 20 million people could get vaccinated in the next several weeks, US Health and Human Services Secretary Alez Azar told CNN on Wednesday.
When will it be widely available?
But it will likely be months before the vaccine is widely available to the rest of the population.
Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, told CNN’s Chris Cuomo on Thursday night that the groups receiving the vaccine in December, January, February and March will likely include those in “high priority groups.”
“I would project by the time you get to April, it will be … ‘open season,’ in the sense of anyone, even the non-high priority groups could get vaccinated,” Fauci said.
In the meantime, it’s important that people continue to wear masks and social distance.
How many doses will be available?
It’s important to note, however, that Pfizer’s vaccine requires two doses administered several weeks apart to reach 95% efficacy. So 100 million doses would vaccinate half the number of people.
Again, not all of those doses will be available at once. Azar said earlier this month that 6.4 million doses of Pfizer vaccine would be allocated for shipment the first week. The initial shipment would include half of the doses, followed by the second half three weeks later.
States will be getting shipments of the vaccine once a week to begin with, Operation Warp Speed chief adviser Moncef Slaoui said Friday, and governors will be told a week in advance how many doses they will be getting.
The number of doses will increase weekly because manufacturing will ramp up, Slaoui told CNN’s Jake Tapper.
Slaoui said he believes most doses will be injected within three to four days, but after that, “I think it will take a week.”
There are a number of vaccines in development by other companies as well. Azar told CNN the US has the ability to purchase up to 3 billion doses of vaccines from six manufacturers, including Pfizer, Moderna, AstraZeneca, Johnson & Johnson, Sanofi/GSK and Novavax.
How will the vaccine be shipped?
The first shipments of the vaccine will be sent from a Pfizer facility in Kalamazoo, Michigan. UPS and FedEx have both said they’re standing by to help with distribution following authorization.
FedEx and UPS will be involved in transporting the vaccines on the ground, delivering them to facilities where they will be administered, like hospitals and long-term care facilities.
The vaccine will be shipped in special containers packed with dry ice. Upon arrival at their destination, the vaccines will then be stored in ultra-cold freezers at minus 70 degrees Celsius, or 94 degrees Fahrenheit below zero.
What are the known side effects?
Pfizer’s clinical trials have shown no severe side effects.
According to a briefing document released by the FDA’s vaccine advisory committee, the most common side effects were reactions at the point of injection on the body, fatigue, headache, muscle pain, chills, joint pain and fever.
Severe adverse reactions occurred in less than 4.6% of trial participants and were less frequent in older adults compared to younger participants.
It also remains unclear how safe the vaccine is for other groups, like pregnant women and children under 16.
CNN’s Maggie Fox, Elizabeth Cohen, Jacqueline Howard, Jamie Gumbrecht and Shelby Lin Erdman contributed to this report.