Coronavirus: Trump says this drug has ‘tremendous promise,’ but Fauci’s not spending money on it

Hydroxychloroquine clinical trials

Boulware said he had to get funding from Silicon Valley tycoon David Baszucki for one part of his study, which looks at hydroxychloroquine to prevent development of the disease, and he still doesn’t have funding for the other part, which studies the drug as a treatment for infection.

“With all the money being spent on coronavirus, we should spend funds on medical research on how best to treat people and prevent new infections,” Boulware said.

The Gates Foundation is expected to announce soon that it will be funding hydroxychloroquine research for coronavirus at the University of Washington and New York University, according to multiple sources.

Federal funding for other coronavirus treatments

Other treatments are getting federal funding, and their trials are underway at multiple sites.

Doctors at 11 sites have enrolled between 60 and 70 patients in a study of a sarimulab, according to George Yancopoulos, chief scientific officer for Regeneron, which makes the drug.

In the fight against coronavirus, doctors are studying sarimulab and other antibody treatments that can alter a body’s inflammatory response to a virus.

At least four sites are already enrolling patients to study the effects of another drug called remdesivir, which is designed to keep viruses from replicating: Northwell Health and Montefiore Medical Center, both in New York City; Duke University Medical Center in North Carolina; and the University of Nebraska Medical Center.

NIAID, the institute lead by Fauci, is sponsoring the trials of remdesivir, which is made by the pharmaceutical company Gilead.

At the White House press briefing last week, Fauci tamped down Trump’s enthusiasm for hydroxychloroquine when he was asked if there was any evidence to suggest the drug could be used to prevent coronavirus

“No. The answer is no,” Fauci said, adding that there was only anecdotal evidence that hydroxychloroquine could be an effective therapy for people with coronavirus.

The day after discussing hydroxychloroquine, Fauci made a pointed comment about coronavirus treatments.

“I don’t want anybody to forget that simultaneously with our doing that, we’re also doing randomized clinical trials on a number of candidates,” he said. “We’re talking about remdesivir, other drugs, immune sera, convalescent serum, monoclonal antibodies, all of these are in the pipeline now queuing up to be able to go into clinical trial,” he said.

Researchers credit the advanced stages of the remdesivir and sarimulab trials to the fact that pharmaceutical companies have exclusive rights to these drugs and have an incentive to get studies moving.

Hydroxychloroquine, on the other hand, is an inexpensive generic drug made by several companies, so no one company stands to make much money off it.

Non-pharmaceutical treatments for coronavirus

There are also non-pharmaceutical approaches being researched to treat coronavirus.

The process, known as convalescent serum, involves taking the blood from someone who has recovered from coronavirus and giving some of the blood products to a patient who is suffering from coronavirus.

The hope is that the antibodies in the recovered person’s blood will help the patient.

Two universities are trying to refine the process even further.

Rockefeller University scientists are looking to reproduce antibodies of recovered patients.

“We fish out the really effective antibodies and clone them and make them in big batches like in a huge container you make beer in, and then give it to people,” said Jill Horowitz, executive director of strategic operations at Rockefeller’s laboratory of molecular immunology.

One advantage of this approach is it uses the strongest antibodies, Horowitz said. Another advantage is that while there’s a limited supply of blood from recovered patients, the antibodies can be replicated in large quantities.

Scientists at Baylor College of Medicine plan to recruit people who recovered easily from coronavirus and also those who ended up being hospitalized with it. The doctors would then see if there is a difference in their T-cells, a component of the immune system, and manufacture the components that seemed to aid in an easy recovery.

These tailored approaches would likely take some time to develop and couldn’t be used on coronavirus patients as quickly as drugs like hydroxychloroquine and sarimulab, which are already on the market for other diseases.

“I wouldn’t be so optimistic about these approaches, and I know that’s sad news,” Caplan said.

But Tracey, the researcher at the Feinstein Institutes, said it was worth the fight.

“We’ll win this war. We just have to survive the battle,” he said. =